What NMN is—and why you’ve been hearing about it
NMN (β‑Nicotinamide Mononucleotide) is a naturally occurring nucleotide that your body converts into NAD⁺ (nicotinamide adenine dinucleotide), a master regulator of cellular energy, DNA repair, and metabolic health. As NAD⁺ levels decline with age and stress, aging researchers believe boosting NAD⁺ via NMN supplementation could help counteract that decline. NMN is found in trace amounts in certain vegetables—like broccoli, avocado and cabbage—but the amounts are too small for therapeutic use.
Promising benefits: what human studies suggest so far
a. NAD⁺ Boosting and Metabolic Effects
Clinical trials consistently show that NMN supplementation elevates blood NAD⁺ levels—and metabolite markers, without serious side effects. Animal studies demonstrate that NMN can improve insulin sensitivity, regulate lipids, enhance mitochondrial function, reduce oxidative stress, and support DNA integrity—implicating benefits for metabolic syndrome, vascular aging, neurodegeneration and inflammation.
b. Muscle Performance & Physical Capacity
In one small trial, amateur runners taking 600–1,200 mg/day showed improved aerobic capacity; in older participants (~65+), doses as low as 250 mg/day significantly enhanced grip strength and gait speed in 6–12 weeks.
c. Metabolic Health & Insulin Sensitivity
Meta‑analysis of 12 human studies (≈ 513 participants) found NAD⁺ levels rose, but effects on glucose, cholesterol and triglycerides were not statistically significant—suggesting potential lived benefits that haven’t yet reached rigorous demonstration in humans. Animal data continues to show strong insulin‑sensitizing and fat‑metabolism effects.
d. Emerging Research: Fertility, Sepsis, Bone & Cognitive Function
Recent rodent studies show NMN may restore oocyte quality in aged mice, protect against sepsis‑induced multi‑organ injury, promote bone regeneration, and support neurological resilience via SIRT signaling pathways (SIRT1, SIRT3) and reduced inflammatory cascades. Alzheimer’s and Parkinson’s models also showed cognitive improvements and protection from neurotoxic insults.
Dosage & safety—what we know
a. Common Dosages in Human Trials
Human studies have used doses from 100 mg/day up to 1,200 mg/day. A 2022 study administering 1,200 mg daily for six weeks was deemed safe and well tolerated, with no serious side effects. Many trials use 250–500 mg/day over 6–24 weeks, with safety profiles remaining favorable.
b. Side Effects & Contraindications
NMN is generally well tolerated. Mild side effects—rarely reported—include nausea, headaches or mild flushing, and potential interactions if combined with complex supplements. Experts advise caution in pregnancy, children, cancer patients, or immune‑compromised individuals given uncertain long‑term effects.
Our top 5 tips if you're considering NMN
a. Purity is everything.
We believe the foundation of any effective NMN supplement is uncompromising purity. That’s why we formulate our NMN with ≥99.9% certified purity, verified by an independent lab with public COAs available for every batch. Our product is free from solvents, heavy metals, and contaminants — just clean, research-grade NMN you can trust.
b. Stability without compromise.
Many NMN products require refrigeration or degrade quickly under normal conditions. We’ve solved that. Our NMN remains stable at room temperature — a claim supported by accelerated degradation testing and real-world user feedback. No fridge. No fuss. Just consistent potency.
c. Formulation that respects the science.
We use pure β-NMN, the most widely studied and biologically active form of NMN. Our product comes in powder form, with no fillers, no binders, no additives — ensuring optimal bioavailability and clean absorption. It’s the format most aligned with how NMN is used in clinical research.
d. Transparency should be the norm.
We take transparency seriously. All of our certificates of analysis are publicly available on our website. Every product is batch-traceable, and we clearly disclose our manufacturing origin in the USA, in facilities that follow strict GMP (Good Manufacturing Practices). When it comes to your health, you deserve nothing less than full clarity.
e. A fair price — backed by customer satisfaction
Producing NMN with ≥99.9% purity, full traceability, and independent lab certification comes with real cost — but we believe in keeping our pricing fair and proportionate to the quality we deliver. At Solensis, we don’t cut corners, and we don’t inflate prices with unnecessary marketing. Our focus is on real value, transparency, and trust. That’s why our customers consistently rate us 4.7/5 or higher, reflecting the satisfaction and confidence that come from choosing a product grounded in science and integrity.
A rapidly evolving field: what science is still uncovering
While current research already supports the NAD⁺-boosting effects and excellent safety profile of NMN, we're just beginning to understand the full range of its long-term benefits. The most exciting phase of NMN research is now underway — and the signs are highly promising.
✔️ Larger and longer-term human trials are in progress to investigate how NMN may support brain function, immune response, cardiovascular health, and possibly even healthy lifespan extension. The question is no longer "does it work?" but "how do we optimize its use across different age groups and health conditions?"
✔️ Emerging evidence from preclinical and early human studies suggests potential benefits in fertility, physical recovery, bone regeneration, and neurological resilience. These findings open up novel possibilities for NMN in preventative and integrative health strategies.
✔️ Cutting-edge research is exploring synergistic effects between NMN and other compounds like resveratrol, quercetin, or PQQ, which may amplify NMN’s effectiveness by enhancing NAD⁺ recycling or mitochondrial activity.
✔️ There’s also growing interest in bioavailability breakthroughs—for example, advanced delivery systems (sublingual, liposomal) and a deeper understanding of NMN transporters like Slc12a8, which play key roles in cellular uptake.
In short, NMN is not just another supplement—it’s a cornerstone of modern longevity science. What we know today already supports its use for energy, metabolic health, and performance. What we’re learning next may elevate it to one of the most valuable tools for proactive, personalized wellness in the years ahead.
