Precision Longevity ingredients: the science behind all 8 actives

Precision Longevity brings together eight actives in two vegan capsules, chosen to support NAD+ and cellular aging from several angles at once. This article goes through each ingredient in turn: what it is, why it is in the formula, its dose, and how strong the evidence actually is. No hype, no shortcuts, just what each molecule does and what the research shows.

The actives fall into a few natural roles. Some help build NAD+, some help preserve it, some support the cell's renewal machinery, and some provide antioxidant and mitochondrial defense. Together they cover more of the biology than any single molecule can. Here is the complete list, one by one.

NMN (500 mg)

NMN, or nicotinamide mononucleotide, is a direct precursor of NAD+, the coenzyme cells rely on for energy production, DNA repair, and stress responses. It is converted to NAD+ through the salvage pathway. It is a genuine precursor rather than NAD+ itself, which matters because NAD+ molecules are poorly absorbed while NMN is taken up efficiently.

The human evidence is a large part of why NMN is included. In a randomized, double blind trial, doses from 300 to 1200 mg per day improved aerobic capacity in trained adults, consistent with NMN acting as the immediate NAD+ precursor (Liao et al., Journal of the International Society of Sports Nutrition, 2021). Across the wider body of NMN trials, the elevation of blood NAD+ is one of the most consistently reproduced findings in the field.

Trans-Resveratrol (250 mg)

Resveratrol is a plant polyphenol and a direct sirtuin activator, meaning it helps switch on the enzymes that use NAD+ to carry out DNA repair and metabolic regulation. The formula uses trans-resveratrol, the biologically active form, so the label reflects what is actually usable.

In a randomized clinical trial in healthy adults aged 55 to 65, resveratrol supplementation significantly increased circulating SIRT1, confirming that sirtuin activation is measurable in people, even though the downstream vascular effects studied were modest (Nutrients, 2023). It is included to complement the NAD+ producing side of the formula with sirtuin activation.

Fisetin (100 mg)

Fisetin is a plant flavonoid studied as a senolytic, a compound that helps clear senescent cells. These are cells that have stopped dividing but resist dying, and they release inflammatory signals that work against healthy tissue.

In a widely cited study, intermittent fisetin reduced markers of senescence across multiple tissues in mice, and late life administration improved tissue function and extended both median and maximum lifespan, with few side effects (Yousefzadeh et al., EBioMedicine, 2018). This is preclinical evidence, so it belongs in the mechanism column rather than the proven human outcomes column, but it is among the more compelling senolytic data for a natural compound.

Apigenin (50 mg)

Apigenin is a flavonoid found in chamomile and parsley, included here for a specific job: preserving NAD+. It inhibits CD38, one of the main NAD+ consuming enzymes in the body, and CD38 becomes more active with age.

In a landmark study, apigenin was characterized as an inhibitor of the NAD+ase CD38, and pharmacological inhibition raised intracellular NAD+ levels. In obese mice, apigenin increased NAD+, reduced protein acetylation, and improved aspects of glucose and lipid metabolism through NAD+ dependent pathways (Escande, Chini et al., Diabetes, 2013). The evidence is preclinical, and the role is clear: help the cell hold on to more of the NAD+ it makes.

Eight actives, one formula

Precision Longevity

942 mg of actives in two vegan capsules, with no fillers, binders, or added colorants. Every ingredient is included at a dose supported by its own research. Formulated by Dr. Marion Gruffaz, PhD.

Learn more

Ergothioneine (20 mg)

Ergothioneine is a naturally occurring antioxidant that accumulates in the mitochondria and other high demand tissues. It is sometimes described as a longevity vitamin because the body has a dedicated transporter for it, which suggests a biological role beyond ordinary antioxidants.

The human evidence is observational rather than interventional, and it is worth being precise about that. In a Swedish cohort of over 3,200 adults followed for a median of 21 years, higher blood ergothioneine was associated with a lower risk of coronary disease, cardiovascular mortality, and overall mortality (Smith et al., Heart, 2020). Association is not proof of cause, but it is a clean signal in a large, well characterized population, which is why ergothioneine is part of the antioxidant base.

PQQ (10 mg)

PQQ, or pyrroloquinoline quinone, is a small redox active compound studied for its effect on mitochondria, the parts of the cell that generate energy. Its distinctive feature is its association with mitochondrial biogenesis, the process of making new mitochondria.

In laboratory work, PQQ stimulated mitochondrial biogenesis through CREB phosphorylation and increased PGC-1 alpha expression, a pathway known to regulate the creation of new mitochondria, and it protected cells against several mitochondrial toxins (Chowanadisai et al., Journal of Biological Chemistry, 2010). This is preclinical, cell and animal based evidence. Its role is to support the mitochondrial environment in which NAD+ dependent energy production happens.

Astaxanthin (6 mg)

Astaxanthin is a red carotenoid from microalgae with unusually strong free radical scavenging activity, several times greater than many common antioxidants. It is included to keep the background load of oxidative stress in check, since that stress adds demand to the NAD+ dependent repair machinery.

In a randomized, triple blind, placebo controlled trial, 6 mg of astaxanthin per day for 12 weeks raised total antioxidant capacity and superoxide dismutase while lowering the oxidative stress marker MDA and the inflammatory cytokines IL-1 beta, IL-6, and TNF-alpha (Rostami et al., Frontiers in Endocrinology, 2023). That 6 mg trial dose is exactly the amount used in the formula.

Spermidine (6 mg)

Spermidine is a natural polyamine that triggers autophagy, the process by which cells recycle their own damaged components. Autophagy tends to slow with age, so supporting it is a way to help cells maintain themselves.

Oral spermidine extended lifespan in mice and produced cardioprotective effects through autophagy, and in humans, higher dietary spermidine intake has been associated with lower blood pressure and reduced cardiovascular disease incidence (Eisenberg et al., Nature Medicine, 2016). The mouse data are causal and the human data are observational, and the formula treats each at its honest tier. In this formula the spermidine is derived from wheat germ.

Every dose is a studied dose

The discipline behind the formula is not the number of ingredients but the amount of each one. It is easy to print eight names on a label. It is harder to include each at the dose actually used in the research, which is what separates a real formula from a padded one. Every active here is present at a research-relevant amount: NMN 500 mg, trans-resveratrol 250 mg, fisetin 100 mg, apigenin 50 mg, ergothioneine 20 mg, PQQ 10 mg, astaxanthin 6 mg, spermidine 6 mg, for 942 mg total in two size zero vegan capsules, with nothing added to pad them out.

A note on honesty about evidence, since it runs through this whole list. Some of these actives have human randomized trials behind them, some have observational human data, and some have preclinical cell or animal data. Those tiers are called out ingredient by ingredient above rather than blurred together, because a science led formula is only as credible as the way it describes its own evidence.

Formulated by a PhD scientist

Eight actives, chosen for a reason

Precision Longevity delivers 942 mg of actives at studied doses, third-party tested, with no fillers. Formulated by Dr. Marion Gruffaz, PhD, and backed by a 30-day money-back guarantee.

Shop Precision Longevity

Frequently Asked Questions

References

1. Liao, B., Zhao, Y., Wang, D., Zhang, X., Hao, X., & Hu, M. (2021). Nicotinamide mononucleotide supplementation enhances aerobic capacity in amateur runners: a randomized, double-blind study. Journal of the International Society of Sports Nutrition, 18(1), 54. https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8265078/
2. Rahnama, M., et al. (2023). Sirtuin 1 and Vascular Function in Healthy Women and Men: A Randomized Clinical Trial Comparing the Effects of Energy Restriction and Resveratrol. Nutrients, 15(13), 2949. https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10346321/
3. Yousefzadeh, M. J., Zhu, Y., McGowan, S. J., Angelini, L., Fuhrmann-Stroissnigg, H., Xu, M., ... & Niedernhofer, L. J. (2018). Fisetin is a senotherapeutic that extends health and lifespan. EBioMedicine, 36, 18-28. https://pubmed.ncbi.nlm.nih.gov/30279143/
4. Escande, C., Nin, V., Price, N. L., Capellini, V., Gomes, A. P., Barbosa, M. T., ... & Chini, E. N. (2013). Flavonoid apigenin is an inhibitor of the NAD+ase CD38: implications for cellular NAD+ metabolism, protein acetylation, and treatment of metabolic syndrome. Diabetes, 62(4), 1084-1093. https://diabetesjournals.org/diabetes/article-abstract/62/4/1084/17887
5. Smith, E., Ottosson, F., Hellstrand, S., Ericson, U., Orho-Melander, M., Fernandez, C., & Melander, O. (2020). Ergothioneine is associated with reduced mortality and decreased risk of cardiovascular disease. Heart, 106(9), 691-697. https://pmc.ncbi.nlm.nih.gov/articles/PMC7229907/
6. Chowanadisai, W., Bauerly, K. A., Tchaparian, E., Wong, A., Cortopassi, G. A., & Rucker, R. B. (2010). Pyrroloquinoline quinone stimulates mitochondrial biogenesis through cAMP response element-binding protein phosphorylation and increased PGC-1alpha expression. Journal of Biological Chemistry, 285(1), 142-152. https://pmc.ncbi.nlm.nih.gov/articles/PMC2804159/
7. Rostami, S., Alyasin, A., Saedi, M., Nekoonam, S., Khodarahmian, M., Moeini, A., & Amidi, F. (2023). Astaxanthin ameliorates inflammation, oxidative stress, and reproductive outcomes in endometriosis patients undergoing assisted reproduction: a randomized, triple-blind placebo-controlled clinical trial. Frontiers in Endocrinology, 14, 1144323. https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10067663/
8. Eisenberg, T., Abdellatif, M., Schroeder, S., Primessnig, U., Stekovic, S., Pendl, T., ... & Madeo, F. (2016). Cardioprotection and lifespan extension by the natural polyamine spermidine. Nature Medicine, 22(12), 1428-1438. https://pmc.ncbi.nlm.nih.gov/articles/PMC5806691/